Publications

Eischen-Loges M, Birgani ZT, Selsouli YA, Eijssen L, Rho H, Sthijns MMJPE, van Griensven M, LaPointe VLS, Habibović P. A roadmap of osteogenic differentiation in human mesenchymal stem cells assessed by protein multiplex analysis. European Cells and Materials 2024; 47: 170-89. Read

Neuen SML, Ophelders DRMG, Widowski H, Hütten MC, Brokken T, van Gorp C, Nikkels PGJ, Severens-Rijvers CAH, Sthijns MMJPE, van Blitterswijk CA, Troost FJ, LaPointe VLS, Jolani S, Seiler C, Pillow JJ, Delhaas T, Reynaert NL, Wolfs TGAM. Multipotent adult progenitor cells prevent functional impairment and improve development in inflammation driven detriment of preterm ovine lungs. Regenerative Therapy 2024; 27: 207–217 Read

Bannier-Hélaouët M, Korving J, Ma Z, Begthel H, Giladi A, Lamers MM, van de Wetering WJ, Yawata N, LaPointe VLS, Dickman MM, Kalmann R, Imhoff SM, van Es JH, López-Iglesias C, Peters PJ, Haagmans BL, Wu W, Clevers H. Human conjunctiva organoids to study ocular surface homeostasis and disease. Cell Stem Cell 2024; 31(2): 227–243 Read

Schumacher A, Nguyen TQ, Broekhuizen R, van Griensven M, LaPointe VLS. Structural development of the human fetal kidney: new stages and cellular dynamics in nephrogenesis. bioRxiv 2023. Read

Schumacher A, Joris V, van Griensven M, LaPointe VLS. Ultrastructural comparison of human kidney organoids and human fetal kidneys reveals features of hyperglycemic culture. bioRxiv 2023. Read

Karagöz Z, Passanha F, Robeerst L,van Griensven M, LaPointe VLS, Carlier A. Computational evidence for multi-layer crosstalk between the cadherin-11 and PDGFR pathways. Scientific Reports 2023; 13: 15804. Read

Honasoge KS, Karagöz Z, Goult BT, Wolfenson H, LaPointe VLS, Carlier A. Force-dependent focal adhesion assembly and disassembly: A computational study. Plos Computational Biology 2023; 19(10): e1011500. Read

Feliciano AJ, Soares E, Bosman AW, van Blitterswijk CA, Moroni L, LaPointe VLS, Baker MB Complementary supramolecular functionalization enhances antifouling surfaces: a ureidopyrimidinone-functionalized phosphorylcholine polymer. ACS Biomaterials Science & Engineering 2023; 9(8): 4619–4631. Read

Rademakers T, Sthijns MMJPE, Paulino da Silva Filho O, Joris V, Oosterveer J, Lam TW, van Doornmalen E, van Helden S, LaPointe VLS. Identification of Compounds Protecting Pancreatic Islets against Oxidative Stress using a 3D Pseudoislet Screening Platform. Advanced Biology 2023; e2300264. Read Dataset

Català P, Groen N, LaPointe VLS, Dickman MM. A single‑cell RNA‑seq analysis unravels the heterogeneity of primary cultured human corneal endothelial cells. Scientifc Reports 2023; 13: 9361. Read Dataset

van Velthoven AJH, Utheim TP, Notara M, Bremond-Gignac D, Figueiredo FC, Skottman H, Aberdam D, Daniels JT, Ferrari G, Grupcheva C, Koppen C, Parekh M, Ritter T, Romano V, Ferrari S, Cursiefen C, Lagali N, LaPointe VLS, Dickman MM. Future directions in managing aniridia-associated keratopathy. Survey of Ophthalmology 2023. Read

Baptista D, Birgani ZT, Widowski H, Passanha F, Stylianidis V, Knoops K, Gubbins E, Iriondo C, Skarp P, Rottier RJ, Wolfs TG, LaPointe VLS, Habibović P, Reynaert NL, Giselbrecht S, Truckenmüller R. Polymer film-based microwell array platform for long-term culture and research of human bronchial organoids. Materials Today Bio 2023; 19: 100603. Read

Hafeez S, Aldana AA, Duimel H, Ruiter FAA, Decarli MC, LaPointe VLS, van Blitterswijk CA, Moroni L, Baker MB. Molecular tuning of a benzene‐1, 3, 5‐tricarboxamide supramolecular fibrous hydrogel enables control over viscoelasticity and creates tunable ECM‐mimetic hydrogels and bioinks. Advanced Materials 2023; 2207053. Read

Català P, Vivensang F, van Beek D, Adriaens ME, Dickman MM, LaPointe VLS, Kutmon M. Elucidating the corneal endothelial cell proliferation capacity through an interspecies transcriptome comparison. Advanced Biology 2023; 2300065. Read

Ruiter FAA, King J, Swapnasrita S, Giselbrecht S, Truckenmüller R, LaPointe VLS, Baker MB, Carlier A. Optimization of Media Change Intervals through Hydrogels Using Mathematical Models. Biomacromolecules 2023; 24(2): 604–612. Read

Wieland FC, Schumacher A, Roumans N, van Blitterswijk CA, LaPointe VLS, Rademakers T. Methodological approaches in aggregate formation and microscopic analysis to assess pseudoislet morphology and cellular interactions. Open Research Europe 2022; 2(87): 87.  Read Dataset

Ruiter FAA, Morgan FLC, Roumans N, Schumacher A, Slaats GG, Moroni L, LaPointe VLS, Baker MB. Soft, dynamic hydrogel confinement improves kidney organoid lumen morphology and reduces epithelial–mesenchymal transition in culture. Advanced Science 2022; 9(20): e2200543. Read Dataset

Stell AL, Mohammed SG, de Vries R, Engelse MA, de Koning E, Sthijns MM, LaPointe VLS, van Apeldoorn AA. Systematic evaluation of clinically used biomaterials to determine their suitability for fabrication of beta cell delivery devices. Journal of Immunology and Regenerative Medicine 2022; 100055. Read

Passanha FR, Geuens T, LaPointe VLS . Cadherin-11 influences differentiation in human mesenchymal stem cells by regulating the extracellular matrix via the TGFβ1 pathway. Stem cells 2022; 40(7): 669–677. Read

Sthijns MM, Rademakers T, Oosterveer J, Geuens T, van Blitterswijk CA, LaPointe VLS. The response of three-dimensional pancreatic alpha and beta cell co-cultures to oxidative stress. PLOS ONE 2022; 17(3): e0257578. Read Dataset

Trayford C,  Crosbie D, Rademakers T, van Blitterswijk C,  Nuijts R, Ferrari S, Habibovic P, LaPointe V, Dickman M, van Rijt S. Mesoporous silica-coated gold nanoparticles for multimodal imaging and reactive oxygen species sensing of stem cells. ACS Applied Nano Materials 2022; 5(3): 3237–3251 Read

Schumacher A, Roumans N, Rademakers T, Joris V, Eischen-Loges MJ, van Griensven M, LaPointe VLS. Enhanced microvasculature formation and patterning in iPSC–derived kidney organoids cultured in physiological hypoxia. Frontiers in Bioengineering and Biotechnology 2022; 10: 860138. Read Dataset

Hafeez S, Passanha FR,  Feliciano AJ, Ruiter FAA, Malheiro A, Lafleur RPM, Matsumoto NM, van Blitterswijk C, Moroni L, Wieringa P, LaPointe VLS, Baker MB. Modular mixing of benzene-1, 3, 5-tricarboxamide supramolecular hydrogelators allows tunable biomimetic hydrogels for control of cell aggregation in 3D. Biomaterials Science 2022. Read

Passanha FR, Divinagracia ML, LaPointe VLS. Cadherin-11 regulates cell proliferation via the PDGFRβ–ERK1/2 signaling pathway in human mesenchymal stem cells. Stem Cells 2022; 40(2): 165–174. Read

Passanha FR*, Gomes DB*, Piotrowska J, Students of PRO3011, Moroni L, Baker MB, LaPointe VLS. A comparative study of mesenchymal stem cells cultured as cell-only aggregates and in encapsulated hydrogels. Journal of Tissue Engineering and Regenerative Medicine 2022; 16(1): 14–25. Read

Stell A, Mohammad SG, de Vries R, Engelse MA, de Koning E, Sthijns MMJPE, LaPointe VLS, van Apeldoorn AA. Systematic evaluation of clinically used biomaterials to determine their suitability for fabrication of beta cell delivery devices. Journal of Immunology and Regenerative Medicine 2021; 100055. Read

Català P, Groen N, Dehnen JA, Soares E, van Velthoven AJH, Nuijts RMMA, Dickman MM, LaPointe VLS. Single cell transcriptomics reveals the heterogeneity of the human cornea to identify novel markers of the limbus and stroma. Scientific Reports 2021; 11: 21727. Read Dataset

Sthijns MMJPE, van Blitterswijk CA, LaPointe VLS. Synthetic materials that affect the extracellular matrix via cellular metabolism and responses to a metabolic state. Frontiers in Bioengineering and Biotechnology 2021; 9: 742132. Read

Wieland FC, Sthijns MMJPE, Geuens T, van Blitterswijk CA, LaPointe VLS. The role of pancreatic alpha cells and endothelial cells in the reduction of oxidative stress in pseudoislets. Frontiers in Bioengineering and Biotechnology 2021; 9: 729057. Read Dataset

Passanha F, Geuens T, LaPointe VLS. Sticking together: harnessing cadherin biology for tissue engineering. Acta Biomaterialia 2021; 134: 107–115. Read

Schumacher A, Rookmaker MB, Joles J, Kramann R, Nguyen TQ, van Griensven M, LaPointe VLS. Defining the variety of cell types in developing and adult human kidneys by single-cell RNA sequences. NPJ Regenerative Medicine 2021; 6(1): 45. Read

Català P, Thuret G, Skottman H, Mehta JS, Parekh M, Ní Dhubhghaill S, Collin RWJ, Nuijts RMMA, Ferrari S, LaPointe VLS, Dickman MM. Approaches for corneal endothelium regenerative medicine. Progress in Retinal and Eye Research 2021; 100987. Read

Geuens T*, Ruiter FAA*, Schumacher A, Morgan FLC, Rademakers T, Wiersma LE, van den Berg CW, Rabelink TJ, Baker MBB, LaPointe VLS. Thiol-one cross-linked alginate hydrogel encapsulation modulates the extracellular matrix of kidney organoids by reducing abnormal type 1a1 collagen deposition. Biomaterials 2021; 275: 120976. Read Dataset

Wieland FC, van Blitterswijk CA, van Apeldoorn AA, LaPointe VLS. The functional importance of the cellular and extracellular composition of the islets of Langerhans. Journal of Immunology and Regenerative Medicine 2021; 13: 100048. Read

Reys LL, Vaithilingam V, Sthijns MMJPE, Soares E, Rademakers T, de Vries R, Mohammed S, de Bont D, Jetten M, Hermanns C, Paulino da Silva Filho O, Stell A, Mourad NI, Gianello P, LaPointe VLS, Silva SS, Reis RL, Silva TH, van Apeldoorn AA. Fucoidan hydrogels significantly alleviate oxidative stress and enhance the endocrine function of encapsulated beta cells. Advanced Functional Materials 2021; 31(35): 211205. Read

Karagöz Z, Geuens T, LaPointe VL, van Griensven M, Carlier A. Win, lose or tie: Mathematical modeling of ligand competition at the cell–extracellular matrix interface. Frontiers in Bioengineering and Biotechnology 2021; 9: 657244. Read

Formisano N, Sahin G, Català P, Truckenmüller R, Nuijts RMMA, Dickman MM, LaPointe VLS, Giselbrecht, S. Nanoscale topographies for corneal endothelial regeneration. Applied Sciences 2021; 11: 827. Read

Sthijns MMJPE, Jetten MJ, Mohammad SG, Claessen SMH, de Vries R, Stell A, de Bont D, Engelse MA, Mumcuoglu D, van Blitterswijk CA, Dankers PYW, de Koning EJP, van Apeldoorn AA, LaPointe VLS. Oxidative stress in alpha and beta cells as a selection criterion for biocompatible biomaterials. Biomaterials 2021; 120449. Read Dataset

Van Velthoven AJH, Bertolin M, Barbaro V, Sthijns MMJPE, Nuijts RMMA, LaPointe VLS, Dickman MM, Ferrari S. Increased cell survival of human primary conjunctival stem cells in DMSO-based cryopreservation media. Biopreservation and Biobanking 2021; 19(1): 67–72. Read

Widowski H, Ophelders DRMG, van Leeuwen AJCN, Nikkels PGJ, Severens-Rijvers CAH, LaPointe VLS, Cleutjens JPM, Hütten MC, Kemp MW, Payne MS, Saito M, Usuda H, Newnham JP, Jobe AH, Kramer BW, Delhaas T, Wolfs TGAM, Reynaert NL. Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero. Pediatric Research 2021; 90(3): 549–558. Read

Wieland FC, Sthijns MMJPE, Geuens T, van Blitterswijk CA, LaPointe VLS. The role of alpha cells in the self-assembly of bioengineered islets. Tissue Engineering Part A 2020; 27: 15–16 Read

Passanha FR, Geuens T, Konig S, van Blitterswijk C, LaPointe VLS. Cell culture dimensionality influences mesenchymal stem cell fate through cadherin-2 and cadherin-11. Biomaterials 2020; 254: 120–127. Read Dataset

Català P, Vermeulen W, Rademakers T, van den Bogaerdt A, Kruijt PJ, Nuijts RMMS, LaPointe VLS, Dickman MM. Transport and preservation comparison of preloaded and prestripped-only DMEK grafts. Cornea 2020; 39(11): 1407–1414. Read

Geuens T, van Blitterswijk CA, LaPointe VLS. Overcoming kidney organoid challenges for regenerative medicine. NPJ Regenerative Medicine 2020; 5(8). Read

Sthijns MMJPE, LaPointe VLS, van Blitterswijk CA. Building complex life through self-organization. Tissue Engineering Part A 2019; 25(19–20): 1341–1346. Read

Rademakers T, Horvath JM, van Blitterswijk CA, LaPointe VLS. Oxygen and nutrient delivery in tissue engineering: approaches to graft vascularization. Journal of Tissue Engineering and Regenerative Medicine 2019; 13(10): 1815–1829 Read

Leuning D, Leuning DG, Witjas FMR, Maanaoui M, de Graaf A, Lievers E, Geuens T, Avramut MC, Wiersma LE, van den Berg CW, Sol WMPJ, de Boer H, Wang G, LaPointe V, van der Vlag J, van Kooten C, van den Berg BM, Little MH, Engelse MA, Rabelink AJ. Vascular bioengineering of scaffolds derived from human discarded transplant kidneys using human pluripotent stem cell-derived endothelium. American Journal of Transplantation 2019; 19(5): 1328–1343. Read

Sthijns MMPE, van Blitterswijk CA, LaPointe VLS. Redox regulation in regenerative medicine and tissue engineering: the paradox of oxygen. Journal of Tissue Engineering and Regenerative Medicine 2018; 12(10): 2013–2020. Read

Le BQ, Nurcombe V, Cool SM, van Blitterswijk CA, de Boer J, LaPointe VLS. The components of bone and what they can teach us about regeneration. Materials 2017; 11(1): 14. Read